The second of four Fleming brothers with a hero father an über-wealthy grandfather an overbearing mother oh, Ian the black sheep moody, withdrawn, long hair slicked back exuding the promise of something dashing or daring, risks
in his piercing blue eyes great laugh all the girls flocked to him, his friends lost out to him at Eton his future spy network fatherless boys whose dads had died in World War I he learned German, French a bit of Russian he decided he wanted to write novels but held off, his older brother a young author and Ian flunked the diplomat exam
became a writer for Reuters charming, persuasive, magnetic an iconoclast people liked him in Moscow to cover a sham trial of two English businessmen when he saw the dark hand of Russia murderous, devious in his future spy novels and his book collection growing he treated women the same way: hunt, acquire, shelve
oh, the seductive playboy a smooth rock against which so many reckless women dashed themselves.
Ian the Spy
Left out of his grandfather’s estate the only heir without funds he worked for a living for newspapers, banks and a job as a personal aid to the director of Naval Intelligence laying the groundwork for the greatest intel alliance in history he helped build the CIA as well but never talked about what he did he did start to drink too much during the war his 450 operatives captured Enigma machines to decode Nazi plans
the life or death drama, the risks he recreated while managing a newspaper syndicate during the Cold War a global cadre of reporter spies saving the world from Russian aggression
he rose to the challenge for the rush, oh the rush that incandescent high one only experiences in a moment of greatness he was able to recapture with his writing in his novels on the risks, the wins against the evil empire by the glamorous Brit the dapper super-spy double-oh seven James Bond.
Ian at Goldeneye
He fell in love with a rum punch on arrival fresh fruits, fresh fish the colors, scents, trees swaying palms and mangos warm rain on warm waves caressing the white sand on the island of Jamaica.
He’d lost his first love a sweet Swiss girl at his mother’s demand then Muriel, his love a motorcycle dispatcher killed in the war his married older lover Maud warned him no, not Ann Lady Ann, chaos Ann but he liked her because of her independence her toughness he said she was such a bitch.
On fourteen acres north of Montego Bay he built his home with money from Maud no glass in the windows big sky, turquoise sea blue floors and birds flying in and out natural and peaceful he called it Goldeneye
Ann visiting, leaving a son her husband believed was his own divorce and a marriage Ian didn’t want, violent whippings he maybe did.
Ian as James Bond
Swimming in clear water above parrot fish, barracuda escaping into a hidden world under deadline he sits down at his battered Royal typewriter with the mind of a sexy boy scout
introducing a British ultra-hero attractive to men and women dangerous, exciting, patriotic the ultimate suave spy himself but romanticized a fast car fantasy life: sharp clothes, fine foods whiskey, gin, martinis a string of bedworthy girls a chain of cigarettes in solitude, darkness Scottish melancholy.
After the first sale a Bond every year all done the same way: an early morning swim then hours in the study two months in Jamaica editing in Manhattan retyping in England one after another until even JFK would ask: “What would Bond do?”
Finishing the first book the bang-bang, kiss-kiss he hands in the manuscript in time to marry Ann and suffers for twelve years writing eleven more books smoking, drinking, escaping her mockery, his depression before the final chapter of his filmworthy life: a glass of whiskey and dead at the height of fame.
Hyperglycemia: Pathophysiological Causes, Clinical Consequences, and Laboratory Diagnosis
Author: Davlatyorova Iqbol Alisher qizi
Institution: Tashkent Medical Academy, Urganch Branch – Advanced Training in Clinical Laboratory Diagnostics
Abstract
Hyperglycemia is a clinical and laboratory sign of many systemic metabolic disorders. This article aims to investigate the underlying causes, short- and long-term consequences, and the role of clinical laboratory diagnosis in the early detection and management of hyperglycemia. Key laboratory tests such as fasting glucose, OGTT, HbA1c, and their interpretation in different clinical settings are discussed.
1. Introduction
Glucose is the primary energy source for most cells in the human body. Its level in blood is tightly controlled by a complex hormonal system, mainly insulin. Hyperglycemia refers to an abnormally high concentration of glucose in the blood, typically above 7.0 mmol/L when fasting, and may signal the presence of diabetes mellitus or other endocrine or stress-related disorders.
2. Pathophysiological Mechanisms of Hyperglycemia
Hyperglycemia may result from different mechanisms: decreased insulin production, increased resistance to insulin at the cellular level, or excessive hepatic glucose output. Type 1 diabetes mellitus is caused by autoimmune destruction of pancreatic beta-cells, while type 2 is linked to peripheral insulin resistance. Temporary hyperglycemia can also occur during severe infections, trauma, myocardial infarction, or treatment with corticosteroids.
3. Clinical Manifestations and Complications
Early symptoms of hyperglycemia include polyuria, polydipsia, fatigue, blurred vision, and weight loss. Chronic untreated hyperglycemia leads to serious complications such as nephropathy, retinopathy, peripheral neuropathy, and cardiovascular disease. Acute decompensation may present as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS).
4. Laboratory Diagnosis of Hyperglycemia
Laboratory testing is the cornerstone of diagnosing hyperglycemia. Commonly used tests include:
– Random Blood Glucose: ≥11.1 mmol/L in symptomatic patients.
5. Preanalytical and Analytical Considerations
Proper sample collection (venous plasma, fasting state), avoidance of glycolysis by timely processing, and accurate calibration of analyzers are essential for valid glucose results. Point-of-care testing (glucometers) is useful for self-monitoring, but should not replace lab-based tests for diagnosis.
6. Laboratory Role in Monitoring and Prevention
Laboratory follow-up is key in managing patients with diabetes. Periodic HbA1c testing, renal function tests (creatinine, urine albumin), and lipid profile help prevent complications. Mass screening programs in high-risk populations (obese, hypertensive, family history) are recommended.
7. Conclusion
Hyperglycemia is a complex metabolic condition that requires timely and accurate laboratory diagnosis. Understanding the laboratory parameters, their clinical interpretation, and integration into patient care pathways can significantly reduce the disease burden and improve health outcomes.
Sometimes I created mornings, in the embrace of darkness,
And I groaned and sighed in the heart of pain,
All the time my hand prayed in my heart,
For today’s happiness, God gave me patience.
My happiness has become higher than the UXUT mountain,
My father and mother always gave me support
Yesterday my tears flowed and were my confidant,
Today my fateful sun conquered the sky.
The nightingale that grew from under the thick snow,
Why should we bow to the losses that have come,
We came to live smiling and laughing
Shining like the moon in the sky of trials.
Please don’t put the bird of luck in a cage,
Be with your brothers before the opportunity is too late,
Let each person create a melody of happiness for themselves,
Let the melody they have created surround their home.
Born on June 2, 2005 in the city of Karshi, Kashkadarya region. She received secondary education at school No. 31 in the city, graduated from school with a “Gold Medal”. Currently, she is a 2nd year student at the Faculty of Journalism and Uzbek Philology of the National University of Uzbekistan named after Mirzo Ulugbek. She has been engaged in creativity since her youth, her creative works have been published in Uzbek and world newspapers and in several collection anthologies. Author of the collection anthology “Tafakkur yulduzlari”. Participant of the “China Fest” festival in the field of literature and science, organized jointly with Uzbekistan and China, participant of the international anthology “Создатели новой науки Узбекистан”, participant of the “Ma’rifat elchisi” project, organized jointly with Georgia, holder of the “Ma’rifat elchisi” badge.
Uzbekistan, like a paradise, is a phrase that everyone understands differently. For some, a peaceful and quiet land with a clear sky comes to mind, while for others, warm and delicious bread baked in a tandoor and delicious delicacies are pictured. Just as every country has its own history and future, Uzbekistan has overcome many difficulties to become “Uzbekistan”. Currently, many young people are interested in European culture, pay more attention to foreign languages, and strive to enter Europe. However, we, the youth, must respect European cultures, constantly remember our Uzbek national values, customs, and our ancestors who have amazed the world, and set an example for the whole world. “What are national values?” The question is also often asked.
Main part
Our national values and traditions are understood as the heritage left by our ancestors, religious beliefs, hospitality, love for language and homeland. In particular, respect for our national values, respect for our native language, and the history of our past should be known to everyone and we should all be proud of it. We should proudly present our national clothes, including atlases, adras and Uzbek skullcaps, to the whole world. My dear President Sh.M. Miromonovich declared every Friday in our country as “National Clothing” Day in order to prevent our national values from disappearing and developing. We have set an example for young people and are celebrating this day with pride, appreciating our national clothes and making them feel our national values.
Conclusion
We, the youth, will further elevate our New Uzbekistan with our own thinking and potential, taking our national values as an example, taking our ancestors Amir Temur, Al-Bukhari, Al-Khwarizmi, and Al-Farghani as an example. Today’s youth are the successors and promoters of our national values. If every young man and woman deeply studies these values and applies them in society, spiritual upliftment will be ensured in society.
Dilnura Khahhorova was born in 2011. She is currently an 8th grade student at school No. 338 in the Mirzo Ulugbek district of Tashkent city. Due to her interest in her native language and literature, she has won honorable places and major prizes in many creative works at the school and district levels. At the same time, she has her place in every competition and event held at the school. Her creative work is published in the book “Ilhom tomchilari”.
Mary Bone has been writing poetry and short stories since childhood. Some of her poems have appeared in Synchronized Chaos, Poetry Catalog, Literary Revelations, Active Muse Journal, Blaze Vox Spring Journal of Voice and other places. Upcoming poetry has been accepted at Feed the Holy and Our Poetry Archive.
Rhian Elizabeth’s maybe i’ll call gillian anderson speaks to the liminal spaces we experience as we transition from one role to another in our relationships.
The book begins with the titular piece where a lonely mom says goodbye to a daughter moving away to college. Next, the same narrator has an elaborate dream of befriending an elderly stranger who comforts her after the loss of her own grandmother and father (drowning on a stranger’s couch). Other pieces depict a mom who feels needed again while caring for a drunken teenager (a new and precarious thing) and a still-grieving queer woman who remembers how in an ill-fated relationship, her lover’s snoring sounded too much like her deceased grandmother’s tea kettle (to the girl who said i’ll never be happy because i’m too picky).
Grief becomes a motif in this collection, which includes pieces referencing the losses of the narrator’s father, grandmother, and past lovers. Sometimes the losses are the focus of the poems, other times they’re mentioned as asides adding depth to a piece on another topic. The daughter’s move towards adulthood becomes a catalyst for the narrator to take stock of her life and consider how she will navigate 40 years of grief and self-discovery.
The prose is all lower case with contractions and some punctuation shorthands (the & sign) giving the book a familiar feeling, like reading the narrator’s Instagram posts. In keeping with this, she includes tidbits of unglamorous daily life: killing spiders, vomiting, drinking soda for breakfast.
She also speaks openly of trauma from verbal abuse at work (glasgow) and sexual abuse from a creepy older man (the photograph & the man who took it). And, of her own awkward past, complete with mornings hung over with strange women in her bed (i drank too much and woke up in sweden next to a blonde) and a relationship that made her feel like a trapped lobster in a cage (lobster).
Dreams and dream-states serve as another motif in this collection. Characters have actual dreams, sleepwalk, get lost and knock on the wrong doors, have lengthy waking reveries, and drive through fog. Being halfway between waking and sleeping echoes the liminal spaces in which the narrator finds herself and also the dislocation of grief and of major life transitions.
In the end, the book comes full circle, checking in with the lonely mother whose daughter left home (i didn’t call gillian anderson). Remembering that she “learned a long time ago that beautiful women aren’t the solution to [her] problems and because, you know, [she doesn’t] have her fucking phone number,” she decides against calling actress Gillian Anderson. Instead, she finds her confidence and her center, meditating, going back to school, reconnecting with friends, and nervously wishing her daughter all the best.
